Dynamic Histone H3 Incorporation Fuels Metastatic Progression

Iva Simeonova; Geneviève Almouzni

doi:10.1016/j.molmed.2019.09.003

Dynamic Histone H3 Incorporation Fuels Metastatic Progression

Trends Mol Med. 2019 Nov;25(11):933-935. doi: 10.1016/j.molmed.2019.09.003. Epub 2019 Oct 14.

Authors

Iva Simeonova¹, Geneviève Almouzni²

Affiliations

¹ Chromatin dynamics, Equipe Labellisée Ligue contre le Cancer, Institut Curie 75005, Paris, France; CNRS (French National Center for Scientific Research), Nuclear Dynamics unit UMR3664, Paris, France; Sorbonne Université 75005, Paris, France; PSL Research University, Paris, France.
² Chromatin dynamics, Equipe Labellisée Ligue contre le Cancer, Institut Curie 75005, Paris, France; CNRS (French National Center for Scientific Research), Nuclear Dynamics unit UMR3664, Paris, France; Sorbonne Université 75005, Paris, France; PSL Research University, Paris, France. Electronic address: genevieve.almouzni@curie.fr.

PMID: 31624022
DOI: 10.1016/j.molmed.2019.09.003

Abstract

Treating metastatic cancers is an ongoing challenge in oncology. A recent paper by Gomes and colleagues proposes histone H3 variant dynamics as major regulator of cell fate transition during metastasis and suggests histone chaperones as therapeutic targets for invasive carcinoma.

Keywords: CAF-1; chromatin reprogramming; histone H3 dynamics; metastasis.

Publication types

Review

MeSH terms

Chromatin / metabolism
Histone Chaperones / metabolism*
Histones / metabolism*
Humans
Neoplasm Metastasis / pathology*
Neoplasms / pathology

Substances

Chromatin
Histone Chaperones
Histones