Abstract
In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these mechanisms suggest possible therapeutic approaches for patients with PTEN-null tumors.
Keywords:
PI3K; PTEN; cancer.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Humans
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Molecular Targeted Therapy*
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Mutation / genetics
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Neoplasms / genetics*
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Neoplasms / pathology
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PTEN Phosphohydrolase / genetics*
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Phosphatidylinositol 3-Kinases / genetics
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Proto-Oncogene Proteins c-akt / genetics
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Signal Transduction / genetics
Substances
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Proto-Oncogene Proteins c-akt
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PTEN Phosphohydrolase
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PTEN protein, human