Multifaceted roles of COPII subunits in autophagy

Zhongyu Li; Wei Huang; Wei Wang

doi:10.1016/j.bbamcr.2019.118627

Multifaceted roles of COPII subunits in autophagy

Biochim Biophys Acta Mol Cell Res. 2020 Apr;1867(4):118627. doi: 10.1016/j.bbamcr.2019.118627. Epub 2019 Dec 19.

Authors

Zhongyu Li¹, Wei Huang¹, Wei Wang²

Affiliations

¹ Department of Human Anatomy, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Human Anatomy, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: wekle@hust.edu.cn.

PMID: 31863790
DOI: 10.1016/j.bbamcr.2019.118627

Abstract

COPII vesicles mediate anterograde ER-Golgi traffic of newly synthesized proteins in nutrient rich conditions. An accumulating body of results indicates that the secretory COPII vesicles can be shifted to the roles in autophagosome formation and selective ER-phagy (autophagy of ER), depending on their specific subunits, in response to environmental stresses. In this mini-review, we summarize and discuss the multifaceted roles of COPII vesicles in autophagy and the underlying molecular mechanisms.

Keywords: Autophagy; COPII; ER-Golgi traffic; ER-phagy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autophagy*
COP-Coated Vesicles / metabolism*
Endoplasmic Reticulum / metabolism
Golgi Apparatus / metabolism
Humans
Vesicular Transport Proteins / metabolism*

Substances

Vesicular Transport Proteins