Tris(2,3-dibromopropyl) phosphate: mutagenicity of a widely used flame retardant

Science. 1977 Jan 7;195(4273):76-8. doi: 10.1126/science.318761.

Abstract

Tris(2,3-dibromopropyl) phosphate, a widely used flame-retardant additive for textiles, is mutagenic to histidine-requiring strains of Salmonella typhimurium. Extracts of fabrics treated with this compound are also capable of inducing mutations in these bacterial strains.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biological Assay
  • Clothing / adverse effects*
  • Dose-Response Relationship, Drug
  • Hydrocarbons, Brominated
  • Microsomes, Liver / metabolism
  • Mutagens*
  • Organophosphorus Compounds / adverse effects*
  • Organophosphorus Compounds / metabolism
  • Rats
  • Salmonella typhimurium / drug effects
  • Skin / metabolism

Substances

  • Hydrocarbons, Brominated
  • Mutagens
  • Organophosphorus Compounds