Metabolic Reprogramming and Vulnerabilities in Cancer

Costas A Lyssiotis; Deepak Nagrath

doi:10.3390/cancers12010090

Metabolic Reprogramming and Vulnerabilities in Cancer

Cancers (Basel). 2019 Dec 30;12(1):90. doi: 10.3390/cancers12010090.

Authors

Costas A Lyssiotis^{1

2

3}, Deepak Nagrath^{4

5

6}

Affiliations

¹ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
² Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
³ Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
⁴ Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
⁵ Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
⁶ Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Metabolic programs are rewired in tumors to support growth, progression, and immune evasion. A wealth of work in the past decade has delineated how these metabolic rearrangements are facilitated by signaling pathways downstream of oncogene activation and tumor suppressor loss. More recently, this field has expanded to include metabolic interactions among the diverse cell types that exist within a tumor and how this impacts the immune system. In this special issue, 17 review articles discuss these phenomena, and, alongside four original research manuscripts, the vulnerabilities associated with deregulated metabolic programming are highlighted and examined.

Keywords: amino acids; cancer associated fibroblasts; cancer metabolism; carbohydrates; iron; lipids; nucleotides; reactive oxygen species; redox; tumor microenvironment.

Publication types

Editorial

Grants and funding

R37 CA237421/CA/NCI NIH HHS/United States