The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved!

Cell Metab. 2020 Jan 7;31(1):13-15. doi: 10.1016/j.cmet.2019.12.007.

Abstract

Although confirmed as the primary lipophilic antioxidant molecule endogenously produced by cells, the non-mitochondrial pool of CoQ10's functional role is still well debated. Recently, both Bersuker et al. (2019) and Doll et al. (2019) have identified FSP1 as a novel CoQ10 plasma membrane oxidoreductase, protecting cells from glutathione-independent ferroptosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Antioxidants*
  • Ferroptosis
  • Glutathione*
  • Ubiquinone / analogs & derivatives

Substances

  • Antioxidants
  • Ubiquinone
  • coenzyme Q10
  • Glutathione