Effect of long-acting β-agonists/glucocorticoids on human airway epithelial cell cytokine, transcriptomic and oxidative stress responses to cannabis smoke

Ryan D Huff; Jennifer A Aguiar; Wayne Tse; Martin R Stämpfli; Brendan J McConkey; Andrew C Doxey; Jeremy A Hirota

doi:10.1183/23120541.00265-2019

Effect of long-acting β-agonists/glucocorticoids on human airway epithelial cell cytokine, transcriptomic and oxidative stress responses to cannabis smoke

ERJ Open Res. 2020 Jan 20;6(1):00265-2019. doi: 10.1183/23120541.00265-2019. eCollection 2020 Jan.

Authors

Ryan D Huff^{1

2}, Jennifer A Aguiar^{3

2}, Wayne Tse¹, Martin R Stämpfli^{4

5}, Brendan J McConkey^{3

4}, Andrew C Doxey^{3

4

6}, Jeremy A Hirota^{1

3

4

5

6}

Affiliations

¹ Division of Respiratory Medicine, Dept of Medicine, University of British Columbia, Vancouver, BC, Canada.
² Joint first authors.
³ Dept of Biology, University of Waterloo, Waterloo, ON, Canada.
⁴ Firestone Institute for Respiratory Health - Division of Respirology, Dept of Medicine, McMaster University, Hamilton, ON, Canada.
⁵ McMaster Immunology Research Centre, Dept of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
⁶ Joint senior authors.

Abstract

LABA/GC intervention in airway epithelial cells exposed to cannabis smoke reduces levels of pro-inflammatory (CXCL8) and antiviral (CXCL10) mediators, while transcriptomic signatures of neutrophil-mediated immunity and oxidative stress remain elevated http://bit.ly/2qiSQhH.