Abstract
Cancer proliferation and progression involves altered metabolic pathways as a result of continuous demand for energy and nutrients. In the last years, cell cycle regulators have been involved in the control of metabolic processes, such as glucose and insulin pathways and lipid synthesis, in addition to their canonical function controlling cell cycle progression. Here we describe recent data demonstrating the role of cell cycle regulators in the metabolic control especially in studies performed in cancer models. Moreover, we discuss the importance of these findings in the context of current cancer therapies to provide an overview of the relevance of targeting metabolism using inhibitors of the cell cycle regulation.
Keywords:
Cancer; Cell cycle; Cyclin-dependent kinases; Cyclins; Metabolic adaptation; Metabolism; Mitochondria.
Copyright © 2020 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Carcinogenesis / drug effects
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Carcinogenesis / genetics
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Carcinogenesis / pathology
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Cell Cycle / drug effects
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Cell Cycle / genetics
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Cell Line, Tumor
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Cyclin-Dependent Kinase Inhibitor Proteins / genetics
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Cyclin-Dependent Kinase Inhibitor Proteins / metabolism*
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Cyclin-Dependent Kinases / antagonists & inhibitors
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Cyclin-Dependent Kinases / genetics
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Cyclin-Dependent Kinases / metabolism*
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Cyclins / genetics
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Cyclins / metabolism*
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Disease Models, Animal
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Disease Progression
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Energy Metabolism / drug effects
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Energy Metabolism / physiology
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Gene Expression Regulation, Neoplastic / drug effects
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Humans
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Mitochondria / drug effects
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Mitochondria / metabolism
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Mutation
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Neoplasms / drug therapy
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Neoplasms / genetics
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Neoplasms / pathology*
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Protein Kinase Inhibitors / pharmacology
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Protein Kinase Inhibitors / therapeutic use*
Substances
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Cyclin-Dependent Kinase Inhibitor Proteins
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Cyclins
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Protein Kinase Inhibitors
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Cyclin-Dependent Kinases