Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine

S Pützer; L Varghese; J von Jan; T Braun; A K Giri; P Mayer; N Riet; S Timonen; S Oberbeck; H Kuusanmäki; S Mustjoki; M-H Stern; T Aittokallio; S Newrzela; A Schrader; M Herling

doi:10.1038/s41375-020-0772-6

Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine

Leukemia. 2020 Sep;34(9):2513-2518. doi: 10.1038/s41375-020-0772-6. Epub 2020 Feb 25.

Authors

S Pützer^{1

2

3}, L Varghese^{1

2

3}, J von Jan^{1

2

3}, T Braun^{1

2

3}, A K Giri⁴, P Mayer^{1

2

3}, N Riet^{1

3}, S Timonen^{4

5

6

7}, S Oberbeck^{1

2

3}, H Kuusanmäki^{4

5

6

7}, S Mustjoki^{5

6

7}, M-H Stern⁸, T Aittokallio^{4

9}, S Newrzela¹⁰, A Schrader^#^{1

2

3}, M Herling^#^{11

12

13}

Affiliations

¹ Department of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf (CIO ABCD), University of Cologne (UoC), Cologne, Germany.
² Excellence Cluster for Cellular Stress Response and Aging-Associated Diseases (CECAD), UoC, Cologne, Germany.
³ Center for Molecular Medicine Cologne (CMMC), UoC, Cologne, Germany.
⁴ Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
⁵ Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
⁶ Hematology Research Unit Helsinki, Helsinki University Hospital, Comprehensive Cancer Center, Helsinki, Finland.
⁷ Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
⁸ INSERM U830, Institut Curie, PSL Research University, Paris, 75013, France.
⁹ Department of Mathematics and Statistics, University of Turku, Turku, Finland.
¹⁰ Senckenberg Institute of Pathology, Goethe-University, Frankfurt am Main, Germany.
¹¹ Department of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf (CIO ABCD), University of Cologne (UoC), Cologne, Germany. marco.herling@uk-koeln.de.
¹² Excellence Cluster for Cellular Stress Response and Aging-Associated Diseases (CECAD), UoC, Cologne, Germany. marco.herling@uk-koeln.de.
¹³ Center for Molecular Medicine Cologne (CMMC), UoC, Cologne, Germany. marco.herling@uk-koeln.de.

^# Contributed equally.

PMID: 32099034
DOI: 10.1038/s41375-020-0772-6

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Alkylating / pharmacology*
Apoptosis / drug effects
Benzimidazoles / pharmacology*
Histone Deacetylase Inhibitors / pharmacology*
Humans
Leukemia, T-Cell / genetics
Leukemia, T-Cell / pathology*
Mutation
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism*

Substances

Antineoplastic Agents, Alkylating
Benzimidazoles
Histone Deacetylase Inhibitors
TP53 protein, human
Tumor Suppressor Protein p53
tinostamustine