Evolutionary consequences of feedbacks between within-host competition and disease control

Megan A Greischar; Helen K Alexander; Farrah Bashey; Ana I Bento; Amrita Bhattacharya; Mary Bushman; Lauren M Childs; David R Daversa; Troy Day; Christina L Faust; Molly E Gallagher; Sylvain Gandon; Caroline K Glidden; Fletcher W Halliday; Kathryn A Hanley; Tsukushi Kamiya; Andrew F Read; Philipp Schwabl; Amy R Sweeny; Ann T Tate; Robin N Thompson; Nina Wale; Helen J Wearing; Pamela J Yeh; Nicole Mideo

doi:10.1093/emph/eoaa004

Evolutionary consequences of feedbacks between within-host competition and disease control

Evol Med Public Health. 2020 Feb 4;2020(1):30-34. doi: 10.1093/emph/eoaa004. eCollection 2020.

Authors

Megan A Greischar¹, Helen K Alexander², Farrah Bashey³, Ana I Bento⁴, Amrita Bhattacharya³, Mary Bushman⁵, Lauren M Childs⁶, David R Daversa^{7

8}, Troy Day⁹, Christina L Faust¹⁰, Molly E Gallagher⁵, Sylvain Gandon¹¹, Caroline K Glidden¹², Fletcher W Halliday¹³, Kathryn A Hanley¹⁴, Tsukushi Kamiya¹, Andrew F Read¹⁵, Philipp Schwabl¹⁰, Amy R Sweeny², Ann T Tate¹⁶, Robin N Thompson^{2

17

18}, Nina Wale¹⁹, Helen J Wearing²⁰, Pamela J Yeh²¹, Nicole Mideo¹

Affiliations

¹ Department of Ecology & Evolutionary Biology, University of Toronto, 25 Willcocks St., Toronto, ON M5S 3B2, Canada.
² Department of Zoology, University of Oxford, Zoology Research and Administration Building, 11a Mansfield Road, Oxford OX1 3SZ, UK.
³ Department of Biology, Indiana University, 1001 E. 3rd St., Bloomington, IN 47405, USA.
⁴ Odum School of Ecology and the Center for the Ecology of Infectious Diseases, University of Georgia, 140 E Green St., Athens, GA 30602, USA.
⁵ Department of Biology, Emory University, Atlanta, GA 30322, USA.
⁶ Department of Mathematics, McBryde Hall, Virginia Tech, Blacksburg, VA 24061, USA.
⁷ Institute of Integrative Biology, University of Liverpool, Liverpool, L69 3BX, UK.
⁸ Institute of Zoology, Zoological Society of London, Regent's Park, NW1 4RY, UK.
⁹ Departments of Mathematics & Biology, Jeffery Hall, Queen's University, Kingston, ON K7L 3N6, Canada.
¹⁰ Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
¹¹ CEFE UMR 5175, CNRS - Université de Montpellier, Université Paul-Valéry Montpellier, EPHE, 1919, Route de Mende, 34293 Montpellier Cedex 5, France.
¹² Department of Integrative Biology, Oregon State University, 3029 Cordley Hall Corvallis, OR 97331, USA.
¹³ Department of Evolutionary Biology and Environmental Studies, University of Zürich, Zürich, 8057, Switzerland.
¹⁴ Department of Biology, New Mexico State University, Foster Hall, Las Cruces, NM 88003, USA.
¹⁵ Center for Infectious Disease Dynamics, Huck Institutes for the Life Sciences; Departments of Biology and Entomology, Pennsylvania State University, University Park, PA 16802, USA.
¹⁶ Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
¹⁷ Mathematical Institute, University of Oxford, Woodstock Road, Oxford OX2 6GG, UK.
¹⁸ Christ Church, University of Oxford, St Aldates, Oxford OX1 1DP, UK.
¹⁹ Department of Ecology & Evolutionary Biology, University of Michigan, 1105 North University Ave, Biological Sciences Building, Ann Arbor, MI 48109, USA.
²⁰ Departments of Biology and Mathematics & Statistics, The University of New Mexico, Albuquerque, NM 87131, USA.
²¹ Department of Ecology & Evolutionary Biology, University of California, Los Angeles, 621 Charles E Young Dr South, Los Angeles, CA 90095, USA.

Abstract

Lay Summary: Competition often occurs among diverse parasites within a single host, but control efforts could change its strength. We examined how the interplay between competition and control could shape the evolution of parasite traits like drug resistance and disease severity.