Autophagy Suppresses Breast Cancer Metastasis

Benjamin N Ostendorf; Sohail F Tavazoie

doi:10.1016/j.devcel.2020.02.005

Autophagy Suppresses Breast Cancer Metastasis

Dev Cell. 2020 Mar 9;52(5):542-544. doi: 10.1016/j.devcel.2020.02.005.

Authors

Benjamin N Ostendorf¹, Sohail F Tavazoie²

Affiliations

¹ Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: bostendorf@rockefeller.edu.
² Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: stavazoie@rockefeller.edu.

PMID: 32155434
DOI: 10.1016/j.devcel.2020.02.005

Abstract

Cancer cells need to acquire specific molecular traits in order to spread to distant organs. In this issue of Developmental Cell, Marsh et al. show that autophagy restricts the outgrowth of breast cancer metastases in contrast to its impact on primary tumor progression.

Publication types

Comment

MeSH terms

Animals
Autophagy*
Breast Neoplasms*
Disease Progression
Humans
Intracellular Signaling Peptides and Proteins
Mammary Neoplasms, Animal*
Proteins

Substances

Intracellular Signaling Peptides and Proteins
NBR1 protein, human
Proteins