Chemotherapy and CDK4/6 Inhibition in Cancer Treatment: Timing Is Everything

Cancer Cell. 2020 Mar 16;37(3):265-267. doi: 10.1016/j.ccell.2020.02.007.

Abstract

Chemotherapy remains the main treatment option for patients with several tumor types. In this issue of Cancer Cell, Salvador-Barbero et al. demonstrate that treatment with CDK4/6 inhibitors after application of taxanes (or other chemotherapeutic compounds) strongly potentiates the anti-tumor effect due to repression of DNA repair machinery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adenocarcinoma*
  • Cell Line, Tumor
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinase 6
  • Humans
  • Pancreatic Neoplasms*

Substances

  • CDK4 protein, human
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinase 6