ATACing DNA Methylation during Differentiation

Mol Cell. 2020 Mar 19;77(6):1159-1161. doi: 10.1016/j.molcel.2020.02.026.

Abstract

Distal regulatory elements control gene expression during differentiation. In this issue of Molecular Cell, Barnett et al. (2020) develop a new technology, called ATAC-Me, and discover that removal of DNA methylation is not a pre-requisite for the creation of accessible chromatin at active gene regulatory elements during cellular differentiation.

Publication types

  • Comment

MeSH terms

  • Cell Differentiation
  • Chromatin*
  • DNA Methylation*
  • Regulatory Sequences, Nucleic Acid

Substances

  • Chromatin