Targeting Plasmepsins-An Achilles' Heel of the Malaria Parasite

Jeremy N Burrows; Dominique Soldati-Favre

doi:10.1016/j.chom.2020.03.015

Targeting Plasmepsins-An Achilles' Heel of the Malaria Parasite

Cell Host Microbe. 2020 Apr 8;27(4):496-498. doi: 10.1016/j.chom.2020.03.015.

Authors

Jeremy N Burrows¹, Dominique Soldati-Favre²

Affiliations

¹ Medicines for Malaria Venture, Meyrin 1215, Switzerland. Electronic address: burrowsj@mmv.org.
² Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva 1201, Switzerland.

PMID: 32272073
DOI: 10.1016/j.chom.2020.03.015

Abstract

Recently, two Plasmodium aspartyl proteases were identified as druggable targets impacting parasite survival. In this issue of Cell Host & Microbe, Favuzza et al. describe the optimization of a compound series acting on both targets, heralding the prospect of a new class of antimalarials for clinical studies.

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MeSH terms

Animals
Antimalarials*
Aspartic Acid Endopeptidases
Malaria*
Parasites*

Substances

Antimalarials
Aspartic Acid Endopeptidases
plasmepsin