Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials

Jack Ho Wong; Tzi Bun Ng; Helen Hei Ling Chan; Qin Liu; Gene Chi Wai Man; Chris Zhiyi Zhang; Suzhen Guan; Charlene Cheuk Wing Ng; Evandro Fei Fang; Hexiang Wang; Fang Liu; Xiuyun Ye; Krzysztof Rolka; Ryno Naude; Shuang Zhao; Ou Sha; Chunman Li; Lixin Xia

doi:10.1007/s00253-020-10476-4

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials

Appl Microbiol Biotechnol. 2020 Jun;104(11):4675-4703. doi: 10.1007/s00253-020-10476-4. Epub 2020 Apr 9.

Authors

Jack Ho Wong¹, Tzi Bun Ng^{2

3}, Helen Hei Ling Chan⁴, Qin Liu⁵, Gene Chi Wai Man⁶, Chris Zhiyi Zhang⁷, Suzhen Guan⁸, Charlene Cheuk Wing Ng⁹, Evandro Fei Fang^{10

11}, Hexiang Wang¹², Fang Liu¹³, Xiuyun Ye¹⁴, Krzysztof Rolka¹⁵, Ryno Naude¹⁶, Shuang Zhao¹⁷, Ou Sha¹⁸, Chunman Li¹⁹, Lixin Xia²⁰

Affiliations

¹ State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China. jack1993@yahoo.com.
² School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. tzibunng@cuhk.edu.hk.
³ The Chinese University of Hong Kong (CUHK) Shenzhen Research Institute, Shenzhen, China. tzibunng@cuhk.edu.hk.
⁴ Vita Green Pharmaceuticals (Hong Kong) Limited, Hong Kong, China. helen.chan@vitagreen.com.
⁵ Institute of Plant Nutrition, Agricultural Resources and Environmental Science, Henan Academy of Agricultural Sciences, Zhengzhou, China.
⁶ Department of Orthopedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China.
⁷ State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center and Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, China.
⁸ Department of Social Medicine, College of Public Health, Xinjiang Medical University, Urumqi, China.
⁹ School of Medicine, King's College London, London, UK.
¹⁰ Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
¹¹ The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway.
¹² Department of Microbiology, China Agricultural University, Beijing, China.
¹³ Department of Microbiology, The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin, China.
¹⁴ Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fuzhou, Fujian, China.
¹⁵ Department of Molecular Biochemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, Gdańsk, Poland.
¹⁶ Department of Biochemistry and Microbiology, Nelson Mandela University, Port Elizabeth, 6031, South Africa.
¹⁷ Key Laboratory of Vegetable Postharvest Processing, Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, and Beijing Key Laboratory of Fruits and Vegetable Storage and Processing, Ministry of Agriculture, Beijing, China.
¹⁸ State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China.
¹⁹ State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China. lichunman@szu.edu.cn.
²⁰ State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China. xialixin@szu.edu.cn.

PMID: 32274562
DOI: 10.1007/s00253-020-10476-4

Abstract

This article reviews mushrooms with anti-breast cancer activity. The mushrooms covered which are better known include the following: button mushroom Agaricus bisporus, Brazilian mushroom Agaricus blazei, Amauroderma rugosum, stout camphor fungus Antrodia camphorata, Jew's ear (black) fungus or black wood ear fungus Auricularia auricula-judae, reishi mushroom or Lingzhi Ganoderma lucidum, Ganoderma sinense, maitake mushroom or sheep's head mushroom Grifola frondosa, lion's mane mushroom or monkey head mushroom Hericium erinaceum, brown beech mushroom Hypsizigus marmoreus, sulfur polypore mushroom Laetiporus sulphureus, Lentinula edodes (shiitake mushroom), Phellinus linteus (Japanese "meshimakobu," Chinese "song gen," Korean "sanghwang," American "black hoof mushroom"), abalone mushroom Pleurotus abalonus, king oyster mushroom Pleurotus eryngii, oyster mushroom Pleurotus ostreatus, tuckahoe or Fu Ling Poria cocos, and split gill mushroom Schizophyllum commune. Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes.

Keywords: Apoptosis; Breast cancer; Clinical trials; Mushrooms; Xenograft.

Publication types

Review

MeSH terms

Agaricales / chemistry*
Agaricales / classification*
Animals
Antineoplastic Agents / therapeutic use*
Breast Neoplasms / drug therapy*
Cell Line, Tumor
Clinical Trials as Topic
Complex Mixtures / chemistry
Complex Mixtures / pharmacology
Disease Models, Animal
Female
Humans
Mice
Rats

Substances

Antineoplastic Agents
Complex Mixtures

Abstract

Publication types

MeSH terms

Substances

Grants and funding