NNT in NSCLC: No need to worry?

J Exp Med. 2020 Jun 1;217(6):e20200310. doi: 10.1084/jem.20200310.

Abstract

In this study, Ward et al. (https://doi.org/10.1084/jem.20191689) provide exciting evidence that nucleotide nicotinamide transhydrogenase (NNT), a mitochondrial matrix-located enzyme harnessing the proton gradient to generate NADPH using NADH, markedly contributes to non-small cell lung carcinoma (NSCLC), which is abrogated in the murine C57BL/6J background, a strain known to be deficient in NNT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinogenesis / metabolism
  • Carcinogenesis / pathology
  • Carcinoma, Non-Small-Cell Lung / enzymology*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Humans
  • Lung Neoplasms / enzymology*
  • Lung Neoplasms / pathology
  • Mice
  • Models, Biological
  • NADP Transhydrogenases / metabolism*

Substances

  • NADP Transhydrogenases