Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids

Protein Cell. 2020 Oct;11(10):771-775. doi: 10.1007/s13238-020-00718-6.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus / isolation & purification
  • Betacoronavirus / pathogenicity*
  • Bile Acids and Salts / metabolism
  • Bile Ducts, Intrahepatic / pathology*
  • Bile Ducts, Intrahepatic / virology
  • COVID-19
  • Cell Culture Techniques
  • Coronavirus Infections / complications
  • Coronavirus Infections / pathology*
  • Cytokine Release Syndrome / etiology
  • Cytokine Release Syndrome / physiopathology
  • Cytopathogenic Effect, Viral
  • Epithelial Cells / enzymology
  • Epithelial Cells / pathology
  • Epithelial Cells / virology
  • Humans
  • Hyperbilirubinemia / etiology
  • Liver / pathology*
  • Organoids / pathology
  • Organoids / virology*
  • Pandemics*
  • Peptidyl-Dipeptidase A / analysis
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / pathology*
  • Receptors, Virus / analysis
  • SARS-CoV-2
  • Serine Endopeptidases / analysis
  • Viral Load

Substances

  • Bile Acids and Salts
  • Receptors, Virus
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2
  • Serine Endopeptidases
  • TMPRSS2 protein, human