Structural Insights into the Activation of mTORC1 on the Lysosomal Surface

Trends Biochem Sci. 2020 May;45(5):367-369. doi: 10.1016/j.tibs.2020.02.004. Epub 2020 Feb 27.

Abstract

Using cryo-electron microscopy and molecular characterization, David Sabatini and colleagues provide crucial new insights that validate and expand their model of how amino acids are sensed and signal at the lysosome to activate mechanistic target of rapamycin complex 1 (mTORC1) and cell growth-regulating processes. This work also reveals new therapeutic opportunities for mTORC1-driven diseases.

Publication types

  • Comment

MeSH terms

  • Amino Acids
  • Cryoelectron Microscopy*
  • Lysosomes / metabolism
  • Mechanistic Target of Rapamycin Complex 1 / metabolism
  • Signal Transduction*

Substances

  • Amino Acids
  • Mechanistic Target of Rapamycin Complex 1