Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism

Michael J Lukey; Kai Su Greene; Richard A Cerione

doi:10.1080/23723556.2020.1735284

Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism

Mol Cell Oncol. 2020 Mar 19;7(3):1735284. doi: 10.1080/23723556.2020.1735284. eCollection 2020.

Authors

Michael J Lukey^{1

2}, Kai Su Greene¹, Richard A Cerione¹

Affiliations

¹ Department of Molecular Medicine, Cornell University, Ithaca, NY, USA.
² Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

Abstract

The metabolic microenvironment of tumors is characterized by fluctuating and limited nutrient availability. To survive these conditions, cancer cell-intrinsic mechanisms sense and signal nutritional status. We describe how glutaminase (GLS) is destabilized by lysine succinylation and stabilized by the NAD⁺-dependent desuccinylase sirtuin 5 (SIRT5), coupling nutrient levels to metabolic flux.

Keywords: GLS; SIRT5; cancer-metabolism; glutamine; succinylation.

Abstract

Grants and funding