Salvage Bacteriophage Therapy for a Chronic MRSA Prosthetic Joint Infection

James B Doub; Vincent Y Ng; Aaron J Johnson; Magdalena Slomka; Joseph Fackler; Bri'Anna Horne; Michael J Brownstein; Matthew Henry; Francisco Malagon; Biswajit Biswas

doi:10.3390/antibiotics9050241

Salvage Bacteriophage Therapy for a Chronic MRSA Prosthetic Joint Infection

Antibiotics (Basel). 2020 May 9;9(5):241. doi: 10.3390/antibiotics9050241.

Authors

Affiliations

¹ Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
² Department of Orthopedic surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
³ Adaptive Phage Therapeutics, Gaithersburg, MD 20878, USA.
⁴ Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, MD 21702, USA.

Abstract

This is a case of a 72 year old male with a chronic methicillin-resistant Staphylococcus aureus prosthetic joint infection. After the third intravenous dose of bacteriophage therapy, an unusual, reversible transaminitis prompted stoppage of bacteriophage therapy. Nevertheless, treatment was successful and the patient's severe chronic infection was eradicated.

Keywords: bacteriophage therapy; biofilm; medication induced hepatitis; methicillin resistance Staphylococcus aureus; prosthetic joint infection.

Publication types

Case Reports