Cytosolic Ca2+ oversees the MASs production of pyruvate for the mitochondrial market

Abstract

It is generally accepted that mitochondrial Ca²⁺ controls the pace of mitochondrial bioenergetics and thus ATP production. Szibor et al. challenge this paradigm, proposing that the balance between ATP consumption and production depends on mitochondrial pyruvate supply via the malate-aspartate shuttle (MAS) and is controlled by cytosolic Ca²⁺.

Keywords: Ca(2+); MCU; malate-aspartate shuttle; mitochondrial metabolism.