Classical and Nonclassical Intercellular Communication in Senescence and Ageing

Abstract

Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes that occur individually or simultaneously, which change depending on the physiological or pathological context. The best characterized means of intercellular communication is the release of soluble factors that affect the function of neighboring cells. However, there are many other ways by which cells can communicate with each other. Here, we review the different means of intercellular communication including soluble factors in the context of senescence, ageing, and age-related diseases.

Keywords: SASP; ageing; extracellular vesicles; intercellular communication; metabolites; senescence.