Targeting Tissue Stiffness in Metastasis: Mechanomedicine Improves Cancer Therapy

Jian Zhang; Cynthia A Reinhart-King

doi:10.1016/j.ccell.2020.05.011

Targeting Tissue Stiffness in Metastasis: Mechanomedicine Improves Cancer Therapy

Cancer Cell. 2020 Jun 8;37(6):754-755. doi: 10.1016/j.ccell.2020.05.011.

Authors

Jian Zhang¹, Cynthia A Reinhart-King²

Affiliations

¹ Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
² Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA. Electronic address: cynthia.reinhart-king@vanderbilt.edu.

PMID: 32516585
DOI: 10.1016/j.ccell.2020.05.011

Abstract

Tissue stiffening plays a critical role in cancer progression. In this issue of Cancer Cell, Shen et al. demonstrated that highly activated fibroblasts in metastatic colorectal cancer increase tissue stiffness and angiogenesis. Targeting tissue stiffness improves the outcome of anti-angiogenic therapy and prolongs patient survival.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Bevacizumab
Colonic Neoplasms*
Humans
Immunotherapy
Liver Neoplasms*
Neovascularization, Pathologic / drug therapy

Substances

Bevacizumab

Abstract

Publication types

MeSH terms

Substances

Grants and funding