Cerebral Blood Flow Is Reduced in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing

C Linda M C van Campen; Peter C Rowe; Frans C Visser

doi:10.3390/healthcare8020169

Cerebral Blood Flow Is Reduced in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing

Healthcare (Basel). 2020 Jun 13;8(2):169. doi: 10.3390/healthcare8020169.

Authors

C Linda M C van Campen¹, Peter C Rowe², Frans C Visser¹

Affiliations

¹ Stichting CardioZorg, 2132 HN Hoofddorp, The Netherlands.
² Department of Paediatrics, John Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Introduction: In a study of 429 adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), we demonstrated that 86% had symptoms of orthostatic intolerance in daily life. Using extracranial Doppler measurements of the internal carotid and vertebral arteries during a 30-min head-up tilt to 70 degrees, 90% had an abnormal reduction in cerebral blood flow (CBF). A standard head-up tilt test of this duration might not be tolerated by the most severely affected bed-ridden ME/CFS patients. This study examined whether a shorter 15-min test at a lower 20 degree tilt angle would be sufficient to provoke reductions in cerebral blood flow in severe ME/CFS patients.

Methods and results: Nineteen severe ME/CFS patients with orthostatic intolerance complaints in daily life were studied: 18 females. The mean (SD) age was 35(14) years, body surface area (BSA) was 1.8(0.2) m² and BMI was 24.0(5.4) kg/m². The median disease duration was 14 (IQR 5-18) years. Heart rate increased, and stroke volume index and end-tidal CO₂ decreased significantly during the test (p ranging from <0.001 to <0.0001). The cardiac index decreased by 26(7)%: p < 0.0001. CBF decreased from 617(72) to 452(63) mL/min, a 27(5)% decline. All 19 severely affected ME/CFS patients met the criteria for an abnormal CBF reduction.

Conclusions: Using a less demanding 20 degree tilt test for 15 min in severe ME/CFS patients resulted in a mean CBF decline of 27%. This is comparable to the mean 26% decline previously noted in less severely affected patients studied during a 30-min 70 degree head-up tilt. These observations have implications for the evaluation and treatment of severely affected individuals with ME/CFS.

Keywords: 20 degree tilt table testing; cardiac index; cerebral blood flow; chronic fatigue syndrome; myalgic encephalomyelitis; orthostatic intolerance; postural orthostatic tachycardia syndrome; stroke volume index.