Organelle Biogenesis: ER Shape Influences Lipid Droplet Nucleation

Melissa A Roberts; Ashley Segura-Roman; James A Olzmann

doi:10.1016/j.cub.2020.05.027

Organelle Biogenesis: ER Shape Influences Lipid Droplet Nucleation

Curr Biol. 2020 Jul 6;30(13):R770-R773. doi: 10.1016/j.cub.2020.05.027.

Authors

Melissa A Roberts¹, Ashley Segura-Roman², James A Olzmann³

Affiliations

¹ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
² Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
³ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Chan Zuckerberg Biohub, San Francisco, CA 94720, USA. Electronic address: olzmann@berkeley.edu.

PMID: 32634419
DOI: 10.1016/j.cub.2020.05.027

Abstract

Lipid droplets (LDs) are neutral lipid storage organelles assembled at the endoplasmic reticulum (ER). A new study reveals that the high membrane curvature of ER tubules catalyzes the nucleation of a neutral lipid lens, an early step in LD biogenesis.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Endoplasmic Reticulum / metabolism
Lipid Droplets* / metabolism
Lipid Metabolism
Lipids
Organelle Biogenesis*

Substances

Lipids

Abstract

Publication types

MeSH terms

Substances

Grants and funding