A new way to ignite thermogenesis in human adipose tissue

Anthony R P Verkerke; Shingo Kajimura

doi:10.1038/s41574-020-0390-4

A new way to ignite thermogenesis in human adipose tissue

Nat Rev Endocrinol. 2020 Sep;16(9):475-476. doi: 10.1038/s41574-020-0390-4.

Authors

Anthony R P Verkerke¹, Shingo Kajimura²

Affiliations

¹ Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
² Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. skajimur@bidmc.harvard.edu.

Abstract

Thermogenic adipose tissue is a metabolic sink for excess fuel and is a promising target for the treatment of obesity and type 2 diabetes mellitus. However, hurdles exist in activating thermogenic adipose tissue in humans. A new study developed a drug screening platform utilizing human beige adipose tissue and identified non-canonical activators.

Publication types

Comment

MeSH terms

Adipocytes, Beige*
Adipose Tissue
Adipose Tissue, Brown
Cell- and Tissue-Based Therapy
Drug Discovery
Humans
Metabolic Diseases*
Thermogenesis

Abstract

Publication types

MeSH terms

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