Effects of garlic supplementation on serum inflammatory markers: A systematic review and meta-analysis of randomized controlled trials

Farhang Mirzavandi; Mehdi Mollahosseini; Amin Salehi-Abargouei; Elham Makiabadi; Hassan Mozaffari-Khosravi

doi:10.1016/j.dsx.2020.06.031

Effects of garlic supplementation on serum inflammatory markers: A systematic review and meta-analysis of randomized controlled trials

Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1153-1161. doi: 10.1016/j.dsx.2020.06.031. Epub 2020 Jun 19.

Authors

Farhang Mirzavandi¹, Mehdi Mollahosseini¹, Amin Salehi-Abargouei¹, Elham Makiabadi², Hassan Mozaffari-Khosravi³

Affiliations

¹ Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
² Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Iran.
³ Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: Mozaffari.kh@gmail.com.

PMID: 32673835
DOI: 10.1016/j.dsx.2020.06.031

Abstract

Background and aims: Previous studies have indicated that garlic consumption may be beneficial in improving inflammation. This systematic review and meta-analysis aimed to examine the effect of garlic supplementation on inflammatory biomarkers.

Methods: PubMed/Medline, Scopus and ISI web of science were searched up to February 2019. Random effects model was used to calculate the overall effects on C-reactive protein (CRP), Interleukin-6 (IL-6), and Tumor necrosis factor- α (TNF-α).

Results: 17 randomized controlled trials (RCTs) were included in the meta-analyses. Garlic supplementation significantly reduced the level of circulating CRP (P < 0.05), whereas it did not have any significant effect on IL-6 level (p > 0.05). Sub-group analysis showed that aged garlic extract (AGE) was able to reduce CRP and TNF-α significantly (P < 0.05).

Conclusions: This meta-analysis showed that supplementation with garlic could reduce the level of circulating CRP and AGE could reduce the level of TNF-α and CRP, whereas it had no significant effect on the IL-6 level.

Keywords: C-reactive protein; Inflammation; Interleukin-6; Meta-analysis; Tumor necrosis factor- α.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Dietary Supplements*
Garlic / chemistry*
Humans
Inflammation / blood*
Inflammation / diet therapy*
Inflammation / pathology
Inflammation Mediators / blood*
Prognosis
Randomized Controlled Trials as Topic

Substances

Inflammation Mediators