Necroptosis is SARMful to your health

J Cell Biol. 2020 Aug 3;219(8):e202006090. doi: 10.1083/jcb.202006090.

Abstract

Necroptosis is a cell death pathway involved in inflammation and disease. In this issue, Ko et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201912047) link SARM1, the executioner of Wallerian degeneration of axons, to necroptosis, revealing a unique form of axonal disassembly likely involved in neurodegenerative disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Armadillo Domain Proteins / genetics
  • Armadillo Domain Proteins / metabolism
  • Axons / metabolism
  • Cytoskeletal Proteins / genetics
  • Cytoskeletal Proteins / metabolism
  • Humans
  • Necroptosis*
  • Signal Transduction
  • Wallerian Degeneration*

Substances

  • Armadillo Domain Proteins
  • Cytoskeletal Proteins
  • SARM1 protein, human