Abstract
Necroptosis is a cell death pathway involved in inflammation and disease. In this issue, Ko et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201912047) link SARM1, the executioner of Wallerian degeneration of axons, to necroptosis, revealing a unique form of axonal disassembly likely involved in neurodegenerative disorders.
© 2020 Pierchala.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Armadillo Domain Proteins / genetics
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Armadillo Domain Proteins / metabolism
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Axons / metabolism
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Cytoskeletal Proteins / genetics
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Cytoskeletal Proteins / metabolism
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Humans
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Necroptosis*
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Signal Transduction
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Wallerian Degeneration*
Substances
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Armadillo Domain Proteins
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Cytoskeletal Proteins
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SARM1 protein, human