Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19

Crit Care. 2020 Jul 22;24(1):452. doi: 10.1186/s13054-020-03141-9.

Authors

Sergey A Kornilov¹, Isabelle Lucas², Kathleen Jade², Chengzhen L Dai², Jennifer C Lovejoy², Andrew T Magis²

Affiliations

¹ Institute for Systems Biology, Seattle, WA 401 Terry Ave N, Seattle, WA, 98109-5263, USA. sergey.kornilov@isbscience.org.
² Institute for Systems Biology, Seattle, WA 401 Terry Ave N, Seattle, WA, 98109-5263, USA.

No abstract available

Keywords: ACE2; COVID-19; GGT; Liver function; Metabolic syndrome; SARS-CoV-2.

Publication types

Letter

MeSH terms

Adult
Aged
Aged, 80 and over
Angiotensin-Converting Enzyme 2
Biomarkers / blood
COVID-19
Cohort Studies
Coronavirus Infections / enzymology*
Coronavirus Infections / mortality
Female
Humans
Male
Metabolic Syndrome / epidemiology
Middle Aged
Pandemics
Peptidyl-Dipeptidase A / blood*
Pneumonia, Viral / enzymology*
Pneumonia, Viral / mortality
Severity of Illness Index
Sex Factors
Young Adult

Substances

Biomarkers
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2