Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer

DNA Repair (Amst). 2020 Oct:94:102860. doi: 10.1016/j.dnarep.2020.102860. Epub 2020 Apr 27.

Abstract

UV-damaged DNA binding protein (UV-DDB) is a heterodimeric complex, composed of DDB1 and DDB2, and is involved in global genome nucleotide excision repair. Mutations in DDB2 are associated with xeroderma pigmentosum complementation group E. UV-DDB forms a ubiquitin E3 ligase complex with cullin-4A and RBX that helps to relax chromatin around UV-induced photoproducts through the ubiquitination of histone H2A. After providing a brief historical perspective on UV-DDB, we review our current knowledge of the structure and function of this intriguing repair protein. Finally, this article discusses emerging data suggesting that UV-DDB may have other non-canonical roles in base excision repair and the etiology of cancer.

Keywords: Nucleotide excision repair; Single molecule; Structure-function; UV-DDB; XP-E; Xeroderma pigmentosum.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • DNA Repair*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Genomic Instability
  • Humans
  • Mutation
  • Neoplasms / genetics
  • Neoplasms / metabolism

Substances

  • DDB1 protein, human
  • DDB2 protein, human
  • DNA-Binding Proteins