Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos

Nat Metab. 2020 Aug;2(8):673-675. doi: 10.1038/s42255-020-0264-z. Epub 2020 Aug 10.

Authors

Sushma Sharma¹, Camilla Koolmeister^{2

3}, Phong Tran¹, Anna Karin Nilsson¹, Nils-Göran Larsson^{2

3}, Andrei Chabes⁴

Affiliations

¹ Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.
² Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
³ Max Planck Institute for Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden.
⁴ Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden. andrei.chabes@umu.se.

PMID: 32778836
DOI: 10.1038/s42255-020-0264-z

No abstract available

Publication types

Letter
Comment

MeSH terms

Animals
DNA Polymerase gamma / genetics
DNA, Mitochondrial / genetics
Genomic Instability
Mice
Nucleotides*
Progeria*

Substances

DNA, Mitochondrial
Nucleotides
DNA Polymerase gamma