Cell Cycle Regulation Meets Tumor Immunosuppression

Trends Immunol. 2020 Oct;41(10):859-863. doi: 10.1016/j.it.2020.07.010. Epub 2020 Aug 13.

Abstract

Reciprocal interactions between tumor cells and immune cells shape the tumor microenvironment. Recent studies indicate that enhanced cell cycle activity in cancer cells suppresses antitumor immunity. Herein we discuss potential mechanisms by which cell cycle programs intrinsic to tumor cells are coupled to immune behavior, with consequences for immunotherapy.

Keywords: cell cycle; immune evasion; immunotherapy; tumor immunology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle* / immunology
  • Humans
  • Immunosuppression Therapy*
  • Immunotherapy
  • Neoplasms* / immunology
  • Neoplasms* / therapy
  • Tumor Microenvironment / immunology