Reciprocal interactions between tumor cells and immune cells shape the tumor microenvironment. Recent studies indicate that enhanced cell cycle activity in cancer cells suppresses antitumor immunity. Herein we discuss potential mechanisms by which cell cycle programs intrinsic to tumor cells are coupled to immune behavior, with consequences for immunotherapy.
Keywords: cell cycle; immune evasion; immunotherapy; tumor immunology.
Copyright © 2020 Elsevier Ltd. All rights reserved.