CSF1R Inhibitor Prevents Glioblastoma Recurrence

Cancer Discov. 2020 Oct;10(10):OF1. doi: 10.1158/2159-8290.CD-NB2020-078. Epub 2020 Aug 21.

Abstract

A mouse study suggests that daily doses of a CSF1R inhibitor after radiation therapy can reduce the likelihood of glioblastoma recurrence. Mice that received the inhibitor lived more than twice as long as control animals, and only 20% of them developed recurrent tumors, whereas all control animals did.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Glioblastoma* / drug therapy
  • Macrophages
  • Mice
  • Neoplasm Recurrence, Local / prevention & control
  • Receptor Protein-Tyrosine Kinases
  • Receptors, Granulocyte-Macrophage Colony-Stimulating Factor

Substances

  • Csf1r protein, mouse
  • Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
  • Receptor Protein-Tyrosine Kinases