Loss of RNA-Binding Protein RBMS1 Promotes a Metastatic Transcriptional Program in Colorectal Cancer

Hannah Carter

doi:10.1158/2159-8290.CD-20-0993

Loss of RNA-Binding Protein RBMS1 Promotes a Metastatic Transcriptional Program in Colorectal Cancer

Cancer Discov. 2020 Sep;10(9):1261-1262. doi: 10.1158/2159-8290.CD-20-0993.

Author

Hannah Carter¹

Affiliation

¹ Division of Medical Genetics, Department of Medicine, University of California, San Diego, La Jolla, California. hkcarter@health.ucsd.edu.

PMID: 32873619
DOI: 10.1158/2159-8290.CD-20-0993

Abstract

Yu and colleagues combined computational and experimental techniques to identify a new post-transcriptional regulator of metastatic potential in colon cancer. This study reveals that the RNA-binding protein RBMS1 is a positive regulator of mRNA stability for multiple genes, including the tumor suppressor AKAP12 and a WNT pathway interacting protein, SDCBP, and its loss is a common event associated with poor prognosis.See related article by Yu et al., p. 1410.

Publication types

Comment

MeSH terms

Colonic Neoplasms*
DNA-Binding Proteins
Genes, Tumor Suppressor
Humans
RNA, Messenger
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism
Regulon*
Wnt Signaling Pathway

Substances

DNA-Binding Proteins
RBMS1 protein, human
RNA, Messenger
RNA-Binding Proteins