The mammalian target of rapamycin and the integrated stress response are central cellular hubs regulating translation upon stress. The precise proteins and pathway specificity of translation targets of these pathways remained largely unclear. We recently described a new method for quantitative translation proteomics and found that both pathways control translation of the same sets of proteins.
Keywords: ISR; Translation proteomics; integrated stress response; mTOR; proteostasis; stress; translatome.
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.