Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison

Pantelis Leptourgos; Martin Fortier-Davy; Robin Carhart-Harris; Philip R Corlett; David Dupuis; Adam L Halberstadt; Michael Kometer; Eva Kozakova; Frank LarØi; Tehseen N Noorani; Katrin H Preller; Flavie Waters; Yuliya Zaytseva; Renaud Jardri

doi:10.1093/schbul/sbaa117

Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison

Schizophr Bull. 2020 Dec 1;46(6):1396-1408. doi: 10.1093/schbul/sbaa117.

Authors

Pantelis Leptourgos¹, Martin Fortier-Davy², Robin Carhart-Harris³, Philip R Corlett¹, David Dupuis⁴, Adam L Halberstadt^{5

6}, Michael Kometer⁷, Eva Kozakova^{8

9}, Frank LarØi^{10

11

12}, Tehseen N Noorani⁴, Katrin H Preller⁷, Flavie Waters¹³, Yuliya Zaytseva^{8

14}, Renaud Jardri^{15

16}

Affiliations

¹ Department of Psychiatry, Connecticut Mental Health Center, Yale University, New Haven, CT.
² Institut Jean Nicod, École des Hautes Études en Sciences Sociales, École Normale Supérieure, PSL Research University, Paris France.
³ Imperial College London, London, UK.
⁴ Department of Anthropology, University of Durham, Durham, UK.
⁵ Department of Psychiatry, University of California San Diego, La Jolla, CA.
⁶ Research Service, VA San Diego Healthcare System, San Diego, CA.
⁷ Pharmaco-Neuroimaging and Cognitive-Emotional Processing, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
⁸ Department of Applied Neurosciences and Brain Imaging, National Institute of Mental Health, Klecany, Czechia.
⁹ Department of Psychology, Faculty of Arts, Charles University, Prague, Czechia.
¹⁰ Department of Biological and Medical Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway.
¹¹ Psychology and Neuroscience of Cognition Research Unit, University of Liège, Liège, Belgium.
¹² Norwegian Center of Excellence for Mental Disorders Research, University of Oslo, Oslo, Norway.
¹³ School of Psychological Sciences, The University of Western Australia, Perth, Western Australia.
¹⁴ Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University in Prague, Prague, Czechia.
¹⁵ Univ. Lille, INSERM U1172, CHU Lille, Lille Neuroscience & Cognition Centre (LiNC), Plasticity & SubjectivitY team, Lille, France.
¹⁶ Laboratoire de Neurosciences Cognitives et Computationnelles, ENS, INSERM U960, PSL Research University, Paris, France.

Abstract

The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.

Keywords: Bayesian; computational; hallucinations; psychedelics; psychosis; serotonin.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Review

MeSH terms

Hallucinations / chemically induced
Hallucinations / diagnostic imaging
Hallucinations / etiology
Hallucinations / physiopathology*
Hallucinogens / adverse effects*
Humans
Nerve Net / diagnostic imaging
Nerve Net / drug effects
Nerve Net / physiopathology*
Schizophrenia / complications
Schizophrenia / diagnostic imaging
Schizophrenia / physiopathology*

Substances

Hallucinogens

Abstract

Publication types

MeSH terms

Substances

Grants and funding