Natural history of SARS-CoV-2 infection in healthcare workers in Northern Italy

J Hosp Infect. 2020 Dec;106(4):709-712. doi: 10.1016/j.jhin.2020.08.027. Epub 2020 Sep 24.

Abstract

At present, the time-frame used for the quarantine of individuals with coronavirus disease 2019 (COVID-19) is the entire duration of symptoms plus 14 days after symptom recovery; however, no data have been reported specifically for healthcare workers (HCWs). In the study population of 142 HCWs with COVID-19, the mean time for viral clearance was 31.8 days. Asymptomatic subjects cleared the virus more quickly than symptomatic subjects (22 vs 34.2 days; P<0.0001). The presence of fever at the time of diagnosis was associated with a longer time to viral clearance (relative risk 11.45, 95% confidence interval 8.66-14.25; P<0.0001). These findings may have a significant impact on healthcare strategies for the future management of the COVID-19 pandemic.

MeSH terms

  • Adult
  • COVID-19 / diagnosis
  • COVID-19 / epidemiology
  • COVID-19 / transmission*
  • COVID-19 / virology
  • Coronavirus Infections / epidemiology*
  • Coronavirus Infections / prevention & control*
  • Coronavirus Infections / transmission
  • Disease Transmission, Infectious / prevention & control
  • Female
  • Health Personnel / statistics & numerical data*
  • Hospitalization / statistics & numerical data
  • Humans
  • Italy / epidemiology
  • Male
  • Middle Aged
  • Quarantine / standards
  • SARS-CoV-2 / genetics
  • Viral Load / trends
  • Virus Shedding / drug effects
  • Virus Shedding / physiology