Mitochondrial Ejection for Cardiac Protection: The Macrophage Connection

Alexander Bartelt; Christian Weber

doi:10.1016/j.cmet.2020.09.014

Mitochondrial Ejection for Cardiac Protection: The Macrophage Connection

Cell Metab. 2020 Oct 6;32(4):512-513. doi: 10.1016/j.cmet.2020.09.014.

Authors

Alexander Bartelt¹, Christian Weber²

Affiliations

¹ Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, 80336 Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. Electronic address: alexander.bartelt@med.uni-muenchen.de.
² Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, 80336 Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229HX Maastricht, the Netherlands; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany. Electronic address: christian.weber@med.uni-muenchen.de.

PMID: 33027673
DOI: 10.1016/j.cmet.2020.09.014

Abstract

Mitochondrial dysfunction is a hallmark of heart disease. Nicolás-Ávila et al. (2020) now find that cardiomyocytes eject dysfunctional mitochondria in exopher vesicles, which require elimination by specialized heart-resident macrophages, altogether supporting proper heart function.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Heart Failure* / metabolism
Homeostasis
Humans
Macrophages
Mitochondria*
Myocytes, Cardiac / metabolism