Genetic variations associated with long noncoding RNAs

Jianjun Luo; Runsheng Chen

doi:10.1042/EBC20200033

Genetic variations associated with long noncoding RNAs

Essays Biochem. 2020 Dec 7;64(6):867-873. doi: 10.1042/EBC20200033.

Authors

Jianjun Luo^{1

2}, Runsheng Chen^{1

2}

Affiliations

¹ Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
² University of Chinese Academy of Sciences, Beijing 100049, China.

PMID: 33034354
DOI: 10.1042/EBC20200033

Abstract

Genetic variations, including single nucleotide polymorphisms (SNPs) and structural variations, are widely distributed in the genome, including the long noncoding RNA (lncRNA) regions. The changes at locus might produce numerous effects in a variety of aspects. Multiple bioinformatics resources and tools were also developed for systematically dealing with genetic variations associated with lncRNAs. Moreover, correlation of the genetic variations in lncRNAs with immune disease, cancers, and other disease as well as development process were all included for discussion. In this essay, we summarized how and in what aspects these changes would affect lncRNA functions.

Keywords: Genetic variations; function; long noncoding RNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Computational Biology / methods
Genetic Loci
Genome, Human
Humans
Immune System Diseases / genetics
Neoplasms / genetics
Polymorphism, Single Nucleotide*
RNA, Long Noncoding / genetics*

Substances

RNA, Long Noncoding