Emerging role of long noncoding RNA-encoded micropeptides in cancer

Mujie Ye; Jingjing Zhang; Meng Wei; Baihui Liu; Kuiran Dong

doi:10.1186/s12935-020-01589-x

Emerging role of long noncoding RNA-encoded micropeptides in cancer

Cancer Cell Int. 2020 Oct 16:20:506. doi: 10.1186/s12935-020-01589-x. eCollection 2020.

Authors

Mujie Ye^#^{1

2}, Jingjing Zhang^#³, Meng Wei^{1

2}, Baihui Liu^{1

2}, Kuiran Dong^{1

2}

Affiliations

¹ Department of Pediatric Surgery, Children's Hospital of Fudan University, No.399 Wanyuan Road, Minhang District, Shanghai, 201102 China.
² Key Laboratory of Neonatal Disease, Ministry of Health, Shanghai, 201102 China.
³ Department of Medical Imaging, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210001 China.

^# Contributed equally.

Abstract

Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play various important roles in the development of cancers. The widespread applications of ribosome profiling and ribosome nascent chain complex sequencing revealed that some short open reading frames of lncRNAs have micropeptide-coding potential. The resulting micropeptides have been shown to participate in N6-methyladenosine modification, tumor angiogenesis, cancer metabolism, and signal transduction. This review summarizes current information regarding the reported roles of lncRNA-encoded micropeptides in cancer, and explores the potential clinical value of these micropeptides in the development of anti-cancer drugs and prognostic tumor biomarkers.

Keywords: Cancer; Coding potential; Micropeptide; Open reading frame; lncRNA.

Publication types

Review