Clinical manifestations and factors associated with mortality from COVID-19 in older adults: Retrospective population-based study with 9807 older Brazilian COVID-19 patients

Geriatr Gerontol Int. 2020 Dec;20(12):1177-1181. doi: 10.1111/ggi.14061. Epub 2020 Oct 27.

Abstract

Aim: Older adults are the main risk group for coronavirus disease 2019 (COVID-19). This study aimed to describe the clinical manifestations and factors associated with mortality from COVID-19 among older adults in Brazil.

Methods: A cross-sectional observational study was carried out with data from 9807 cases of COVID-19 among older adults in the state of Alagoas, Brazil. We determined the case fatality rate between age groups and clinical factors associated with mortality.

Results: A total of 52.5% (n = 5145) were women, and with an average age of 70.21 ± 8.37 years. The fatality rate was 11.9%, with a higher rate in men (14.4%) compared with women (9.8%). The fatality rate increased with age. The most common manifestations were fever (n = 4926; 50.2%), cough (n = 5737; 58.5%), headache (n = 1980; 20.2%) and fatigue (n = 2022; 20.6%). The most prevalent comorbidities were diabetes (n = 1528; 5.6%), cardiovascular disease (n = 1528; 15.6%) and systemic arterial hypertension (n = 597; 6.1%). The factors associated with mortality were male sex (OR 1.54), age ≥75 years (OR 2.40), dyspnea (OR 2.92), diabetes (OR 2.33), hypertension (OR 1.53) and chronic kidney disease (OR 2.02).

Conclusions: The profile and the risk factors evidenced show the need to adopt mechanisms to protect the elderly population.

Keywords: COVID-19; elderly; geriatric patients; mortality; risk factors.

Publication types

  • Observational Study

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Brazil
  • COVID-19 / diagnosis
  • COVID-19 / epidemiology*
  • COVID-19 / mortality*
  • COVID-19 / physiopathology
  • Cardiovascular Diseases / epidemiology
  • Comorbidity
  • Cough
  • Cross-Sectional Studies
  • Diabetes Mellitus / epidemiology
  • Dyspnea / epidemiology
  • Fatigue
  • Female
  • Fever
  • Headache
  • Humans
  • Hypertension / epidemiology
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Pandemics
  • Renal Insufficiency, Chronic / epidemiology
  • Retrospective Studies
  • Risk Factors