Bleaching toothpaste with two different concentrations of hydrogen peroxide: A randomized double-blinded clinical trial

Hyun-Jung Kim; Ji-Hyun Jang; Dongseok Choi; Jei Kim; Ji-Hee Shim; Duck-Su Kim

doi:10.1016/j.jdent.2020.103508

Bleaching toothpaste with two different concentrations of hydrogen peroxide: A randomized double-blinded clinical trial

J Dent. 2020 Dec:103:103508. doi: 10.1016/j.jdent.2020.103508. Epub 2020 Oct 26.

Authors

Hyun-Jung Kim¹, Ji-Hyun Jang², Dongseok Choi³, Jei Kim⁴, Ji-Hee Shim⁴, Duck-Su Kim⁵

Affiliations

¹ Department of Conservative Dentistry, Kyung Hee University Dental Hospital, Seoul, Republic of Korea.
² Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea.
³ Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea; Division of Biostatistics, Oregon Health and Science University, Portland State University of Public Health, Oregon Health and Science University, Portland, OR, USA.
⁴ Department of Conservative Dentistry, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
⁵ Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea. Electronic address: dentist96@khu.ac.kr.

PMID: 33121984
DOI: 10.1016/j.jdent.2020.103508

Abstract

Objectives: This randomized double-blinded clinical trial evaluated the bleaching efficacy and incidence of contact hypersensitivity of three kinds of bleaching toothpaste.

Methods: Forty-nine participants above A2 shade on the maxillary central incisor (#11) and canine (#13) were randomized into three groups: TW group (n = 15), 0.75 % HP-containing toothpaste (Toothwhole white); VL group (n = 15), 0.75 % HP-containing toothpaste (Vussen 7); and VH group (n = 17), 2.8 % of HP-containing toothpaste (Vussen 28). Participants were instructed to manually brush their teeth for 3 min, 3 times per day for 12 weeks. They were followed-up after 4 and 12 weeks. Shade measurements were performed using a spectrophotometer (SP), and data were calculated with CIELab (ΔE_ab^*) and CIEDE2000 (ΔE₀₀) formula. Additionally, visual inspection (VI) using the Vitapan classical shade guide was also performed, and the correlation between the two measurements was analyzed by comparing the CIELab (ΔE_ab^*) values. The incidence of contact hypersensitivity at each follow-up was recorded. A mixed-effect model was performed to assess shade changes and chi-square tests for the incidence of contact hypersensitivity, respectively.

Results: At 12 week follow-up, all groups showed ΔE_ab^* above 3.46, and ΔE₀₀ above 2.25 for tooth #11. For tooth #13, the ΔE_ab^* and ΔE₀₀ of VH and TW groups only were above those thresholds. Shade change varied according to toothpaste and follow-up points. SP and VI showed a moderate positive correlation for L*, a*, and b*, respectively (P < 0.05). Contact hypersensitivity was not significantly different among the groups (P > 0.05).

Conclusions: Bleaching toothpaste with higher HP yields a better shade change than other toothpaste after 12 weeks.

Clinical significance: The use of bleaching toothpaste with a higher HP concentration results in a better shade improvement.

Keywords: Bleaching toothpaste; Dental bleaching; Double-blind clinical study; Hydrogen peroxide; Hypersensitivity; Shade measurement.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Hydrogen Peroxide
Tooth Bleaching Agents* / therapeutic use
Tooth Bleaching* / adverse effects
Tooth Discoloration*
Toothpastes / therapeutic use
Treatment Outcome

Substances

Tooth Bleaching Agents
Toothpastes
Hydrogen Peroxide