The Role of Small Noncoding RNA in DNA Double-Strand Break Repair

Iwona Rzeszutek; Gabriela Betlej

doi:10.3390/ijms21218039

The Role of Small Noncoding RNA in DNA Double-Strand Break Repair

Int J Mol Sci. 2020 Oct 28;21(21):8039. doi: 10.3390/ijms21218039.

Authors

Iwona Rzeszutek¹, Gabriela Betlej²

Affiliations

¹ Institute of Biology and Biotechnology, Department of Biotechnology, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland.
² Institute of Physical Culture Studies, College of Medical Sciences, University of Rzeszow, 35-310 Rzeszow, Poland.

Abstract

DNA damage is a common phenomenon promoted through a variety of exogenous and endogenous factors. The DNA damage response (DDR) pathway involves a wide range of proteins, and as was indicated, small noncoding RNAs (sncRNAs). These are double-strand break-induced RNAs (diRNAs) and DNA damage response small RNA (DDRNA). Moreover, RNA binding proteins (RBPs) and RNA modifications have also been identified to modulate diRNA and DDRNA function in the DDR process. Several theories have been formulated regarding the synthesis and function of these sncRNAs during DNA repair; nevertheless, these pathways' molecular details remain unclear. Here, we review the current knowledge regarding the mechanisms of diRNA and DDRNA biosynthesis and discuss the role of sncRNAs in maintaining genome stability.

Keywords: DNA damage response (DDR); double-strand breaks (DSBs), DNA repair; noncoding RNA.

Publication types

Review

MeSH terms

Animals
DNA Breaks, Double-Stranded*
Genomic Instability*
Humans
RNA, Small Untranslated / genetics*
RNA, Small Untranslated / metabolism
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism*

Substances

RNA, Small Untranslated
RNA-Binding Proteins