M6A Regulatory Genes Play an Important Role in the Prognosis, Progression and Immune Microenvironment of Pancreatic Adenocarcinoma

Fangshi Xu; Zhengliang Zhang; Miao Yuan; Yidi Zhao; Yang Zhou; Honghong Pei; Ling Bai

doi:10.1080/07357907.2020.1834576

M6A Regulatory Genes Play an Important Role in the Prognosis, Progression and Immune Microenvironment of Pancreatic Adenocarcinoma

Cancer Invest. 2021 Jan;39(1):39-54. doi: 10.1080/07357907.2020.1834576. Epub 2020 Nov 12.

Authors

Fangshi Xu¹, Zhengliang Zhang², Miao Yuan², Yidi Zhao², Yang Zhou², Honghong Pei², Ling Bai²

Affiliations

¹ Department of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
² Department of Emergency, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.

PMID: 33176521
DOI: 10.1080/07357907.2020.1834576

Abstract

The specific roles of N6-methyladenosine (m6A) regulatory genes in pancreatic adenocarcinoma (PAAD) have not been fully elucidated. In present study, a novel risk signature was constructed by five m6A-related genes (including METTL3, METTL14, KIAA1429, ALKBH5 and YTHDF1) and was identified as an independent prognostic factor (HR = 13.192) via TCGA (185 samples) databases. The immune abundances of 22 leukocyte subtypes in each PAAD sample were exhibited via the CIBERSORT algorithm. High risk group promoted infiltration levels of Macrophages M0 and M2 cells and decreased that of B cells naive, T cells CD8 and T regulatory cells.

Keywords: N6-methyladenosine; Pancreatic adenocarcinoma; immune microenvironment; prognosis; risk signature.

MeSH terms

Adenocarcinoma / genetics*
Adenocarcinoma / mortality
Disease Progression
Gene Expression Regulation, Neoplastic / genetics*
Humans
Methyltransferases / genetics*
Pancreatic Neoplasms / genetics*
Pancreatic Neoplasms / mortality
Prognosis
Survival Analysis
Tumor Microenvironment

Substances

Methyltransferases
METTL3 protein, human