Ubiquitin Tunes Hedgehog in Matters of the Heart

Sandii Constable; Saikat Mukhopadhyay

doi:10.1016/j.devcel.2020.10.017

Ubiquitin Tunes Hedgehog in Matters of the Heart

Dev Cell. 2020 Nov 23;55(4):385-386. doi: 10.1016/j.devcel.2020.10.017.

Authors

Sandii Constable¹, Saikat Mukhopadhyay²

Affiliations

¹ Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: sandra.constable@utsouthwestern.edu.
² Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: saikat.mukhopadhyay@utsouthwestern.edu.

PMID: 33232673
DOI: 10.1016/j.devcel.2020.10.017

Abstract

Oligogenic inheritance makes the etiology of developmental diseases challenging to determine. In this issue of Developmental Cell, Kong et al., 2020 identify members of a membrane-tethered ubiquitin complex that attenuates Hedgehog signaling strength and genetically interact to regulate digit number, body patterning, and cardiac development.

Publication types

Comment

MeSH terms

Body Patterning
Heart
Hedgehog Proteins* / metabolism
Signal Transduction
Ubiquitin*
Ubiquitination

Substances

Hedgehog Proteins
Ubiquitin