Mitotic ER exit site dynamics: insights into blockade of secretion from the ER during mitosis

Miharu Maeda; Yukie Komatsu; Kota Saito

doi:10.1080/23723556.2020.1832420

Mitotic ER exit site dynamics: insights into blockade of secretion from the ER during mitosis

Mol Cell Oncol. 2020 Oct 22;7(6):1832420. doi: 10.1080/23723556.2020.1832420. eCollection 2020.

Authors

Miharu Maeda¹, Yukie Komatsu¹, Kota Saito¹

Affiliation

¹ Department of Biological Informatics and Experimental Therapeutics, Graduate School of Medicine, Akita University, Akita, Japan.

Abstract

How ER exit sites disassemble during mitosis is not well understood. Transport ANd Golgi Organization 1 (TANGO1, also known as MIA3), a cargo receptor originally identified for collagens, acts as a hub for ER exit site disassembly under the control of Casein Kinase 1 (CK1)-mediated phosphorylation and Protein Phosphatase 1 (PP1)-mediated dephosphorylation. Impaired dephosphorylation during mitosis induces ER exit site disassembly.

Keywords: CK1; COPII; PP1; Sec16; Secretion; TANGO1; mitosis.

Grants and funding

This work was supported by Grant-in-Aid for Scientific Research [18H06063, 20K15740 to M.M. 20H01100 to Y.K. and 17H03651, 19K22612, 20H03203, 20H04897 to K.S.] from the Ministry of Education, Culture, Sports, Science and Technology of Japan, by Takeda Science Foundation to K.S., by The Uehara Memorial Foundation to K.S., by The Naito Foundation to K.S., by Toray Science Foundation [19-6005] to K.S., by Tokyo Biochemical Research Foundation to K.S., by KOSE Cosmetology Research Foundation to K.S., by TERUMO Life Science Foundation to K.S., by the Sumitomo Foundation to K.S., by Daiwa Securities Health Foundation to K.S., by Life Science Foundation of Japan to K.S., by The Ichiro Kanahara Foundation for the Promotion of Medical Sciences and Medical Care to K.S., by Akita University Support for Fostering Research Project to M.M., Y.K., and K.S., and by Suzuken Memorial Foundation to M.M.