Autophagy Brings an END to Aberrant Endocytosis

Mol Cell. 2020 Dec 3;80(5):758-759. doi: 10.1016/j.molcel.2020.11.020.

Abstract

Wilfling et al. (2020) characterize a selective autophagy pathway in yeast for early clathrin-mediated endocytosis (CME) proteins facilitated by the phase separation of the CME protein, Ede1, which acts as an intrinsic autophagy receptor for the degradation of Ede1-dependent endocytic protein deposits (ENDs).

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Autophagy
  • Clathrin*
  • Endocytosis
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae Proteins* / genetics

Substances

  • Clathrin
  • Saccharomyces cerevisiae Proteins