Cell Migration Guided by Cell-Cell Contacts in Innate Immunity

Veronika Miskolci; Lucas C Klemm; Anna Huttenlocher

doi:10.1016/j.tcb.2020.11.002

Cell Migration Guided by Cell-Cell Contacts in Innate Immunity

Trends Cell Biol. 2021 Feb;31(2):86-94. doi: 10.1016/j.tcb.2020.11.002. Epub 2020 Dec 3.

Authors

Veronika Miskolci¹, Lucas C Klemm², Anna Huttenlocher³

Affiliations

¹ Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.
² Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA; Molecular and Cellular Pharmacology Graduate Training Program, University of Wisconsin-Madison, Madison, WI, USA.
³ Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: huttenlocher@wisc.edu.

Abstract

The directed migration of leukocytes to sites of damage or infection is necessary for a productive immune response. There is substantial evidence supporting a key role for chemoattractants in directed migration, however, less is known about how cell-cell contacts affect the migratory behavior of leukocytes in innate immunity. Here, we explore how cell-cell contacts can affect the directed migration of innate immune cells, including their role in attracting, repelling, or stopping cell motility. Further investigation of cell contact dynamics as guidance cues may yield new insights into the regulation of innate immunity.

Keywords: cell–cell contact; macrophages; migration; neutrophils.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Communication*
Cell Movement / physiology*
Humans
Immunity, Innate*
Neutrophils / metabolism
Neutrophils / physiology*
Signal Transduction / physiology

Abstract

Publication types

MeSH terms

Grants and funding