Infection by Cryptococcus neoformans, a budding nonmycelial yeast, involves the central nervous system in 70% of patients at the time of diagnosis. Meningitis and meningoencephalitis are common manifestations of infection; solid granulomas occur but are unusual, and intraventricular granulomas are distinctly rare. Two cases of intraventricular cryptococcal granuloma are reported. The diagnosis and treatment of mass lesions due to cryptococcal infection are discussed, with special reference to intraventricular granulomas.