Nuclear Deformation Lets Cells Gauge Their Physical Confinement

Joseph T Long; Jan Lammerding

doi:10.1016/j.devcel.2021.01.002

Nuclear Deformation Lets Cells Gauge Their Physical Confinement

Dev Cell. 2021 Jan 25;56(2):156-158. doi: 10.1016/j.devcel.2021.01.002. Epub 2021 Jan 25.

Authors

Joseph T Long¹, Jan Lammerding²

Affiliations

¹ Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
² Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA. Electronic address: jan.lammerding@cornell.edu.

PMID: 33497620
DOI: 10.1016/j.devcel.2021.01.002

Abstract

How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migration, revealing the nucleus to serve as a central mechanosensor.

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MeSH terms

Cell Line, Tumor
Cell Movement
Cell Nucleus*
Cytoplasm
Proprioception*